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流行性出血热病毒(EHFV)为单股负链RNA病毒,其基因组RNA分为L、M、S三个片段,分别与同一种核壳蛋白结合再被包膜糖蛋白包裹成平均直径122nm(78—210nm)的圆形;卵圆形或多角形颗粒,外层为带突的双层包膜,三个基因片段具有保守的11个碱基完全相同。在感染EHFV的细胞浆内有多发性、特征性的包含体,具有病毒的抗原性,且仅具有病毒核蛋白抗原而不含病毒糖蛋白抗原成份。EHFV四种结构蛋白中,核壳蛋白(IVP)分子量为(50～53KD)、两种包膜蛋白分别为G_1:(65—74KD),G_2:(55—65KD)、L蛋白(200KD),后者可能是依赖RNA的DNA多聚酶。
Epidemic hemorrhagic fever virus (EHFV) is a single-stranded minus-strand RNA virus, the genomic RNA is divided into L, M, S three fragments, respectively, with the same type of nucleocapsid protein and then wrapped glycoprotein wrapped into an average diameter of 122nm 78-210nm) round; oval or polygonal particles, the outer layer with a protruding double-coated, three gene fragments with a conservative 11 bases exactly the same. In the cytoplasm of infected EHFV, there are multiple, characteristic inclusion bodies, which have the antigenicity of the virus and only have the viral nucleoprotein antigens but not the viral glycoprotein antigen components. Among the four structural proteins of EHFV, the molecular weight of nucleocapsid protein (IVP) was (50-53KD). The two envelope proteins were G 1: 65-74KD, G_2: 55-65KD, L protein 200KD, The latter may be RNA-dependent DNA polymerase.