酒精对横纹肌有直接毒性。在慢性酒精中毒时,其肌病可有不同的临床表现,从无症状的血清酶升高到急性横纹肌溶解。肌无力并不一定限于四肢,面肌亦偶可受累。本文报告一例伴酒精性肌病的咽部及邻近食管的骨骼肌无力所致之吞咽困难。患者男性,62岁。30年来每天喝1/2～1品脱酒。就诊前3周开始进行性吞咽困难和四肢无力,吞咽液体及固体食物均感困难,有鼻腔返流和咳嗽、肌无力而卧床不起,肌酸磷酸激酶1511mU/ml。钡透见钡剂滞留于会厌谷和梨状窝,并有气管支气管吸入。食管活动度检查示咽和邻接的6～8cm的食管收缩幅度显著减少,食管上端括约肌的静息峰压值为45mmHg(正常为等于或大 Alcohol is directly toxic to striated muscle. In chronic alcoholism, myopathy may have different clinical manifestations, ranging from asymptomatic serum enzymes to acute rhabdomyolysis. Muscle weakness is not necessarily limited to the limbs, facial muscles can even be involved. This article reports an example of dysphagia due to weakness in the skeletal muscles of the throat and adjacent esophagus with alcoholic myopathy. Male patient, 62 years old. Drink 1/2 ~ 1 pint of wine for 30 years. 3 weeks prior to the onset of sexual dysphagia and limb weakness, swallowing liquid and solid food are difficult, with nasal reflux and cough, muscle weakness and bedridden, creatine kinase 1511mU / ml. Barium see barium retention in the epiglottic valley and pear-shaped nest, and tracheal bronchial inhalation. Esophageal activity examination revealed pharyngeal and adjacent 6 ~ 8cm esophageal contraction amplitude was significantly reduced, resting upper esophageal sphincter peak pressure value of 45mmHg (normal is equal to or greater