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①目的检测神经母细胞瘤Ｐ－糖蛋白（Ｐ－ｇｐ）表达情况并探讨其临床意义。②方法用ＪＳＢ－１Ｐ－ｇｐ单克隆抗体ＳＬＡＢ法，测定１９例神经母细胞瘤石蜡切片的Ｐ－ｇｐ表达情况。③结果１９例神经母细胞瘤有１１例Ｐ－ｇｐ阳性（５７．９％）。术前化疗与术前无化疗的神经母细胞瘤Ｐ－ｇｐ阳性率间差别有显著性（χ２＝４．９２，Ｐ＜０．０５）。Ｐ－ｇｐ阳性组神经母细胞瘤病儿的平均生存时间为３２３ｄ，阴性组为７８９ｄ，二者具有明显差异（时序检验，Ｐ＜０．０５）。④结论Ｐ－ｇｐ表达是神经母细胞瘤产生耐药的原因之一，是预后不良的指标
Objective To detect the expression of P-glycoprotein (P-gp) in neuroblastoma and explore its clinical significance. 2 Methods The P-gp expression of paraffin sections from 19 neuroblastoma specimens was determined by JSB-1P-gp monoclonal antibody SLAB method. 3 Results 11 cases of neuroblastoma were P-gp positive (57.9%). Preoperative chemotherapy and preoperative chemotherapy without neuroblastoma P-gp positive rate difference was significant (χ2 = 4.92, P <0.05). The average survival time of children with neuroblastoma in the P-gp-positive group was 323 days, and the negative group was 789 days. There was a significant difference between the two groups (rank test, P<0.05). 4 Conclusions P-gp expression is one of the causes of drug resistance in neuroblastoma and is an indicator of poor prognosis.