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控制和消灭肝癌最有效的途径是预防,首先的预防策略是消除或避免与致癌物接触。但要消除或避免致癌病因什分困难,况且有一些人可能对肝癌的发生具有遗传易感性。在这些情况下,肝癌的药物预防便具有重要意义。 一、抗氧化剂: (一)羟基甲苯丁酯(BHT)和叔丁基对羟基茴香醚(BHA):它们是防止脂肪变质的食物添加剂。近年Williams研究了BHT和BHA对大鼠AFB_1致肝癌的影响,单独暴露于AFB_1 20周后诱发大量转化病灶,停止暴露24周后,肝癌发生率为63％。暴露AFB_1同时饲BHT和BHA,转化病灶减少,肝细胞癌发生率和每个动物的肿瘤数目亦减少,呈剂量依赖关系。
The most effective way to control and eradicate liver cancer is prevention. The first preventive strategy is to eliminate or avoid contact with carcinogens. However, it is necessary to eliminate or avoid the difficulties caused by carcinogenesis, and some people may have genetic susceptibility to the occurrence of liver cancer. Under these circumstances, drug prevention of liver cancer is of great significance. First, antioxidants: (a) hydroxytoluene butyl ester (BHT) and tert-butyl hydroxy anisole (BHA): They are food additives to prevent fat deterioration. In recent years, Williams studied the effects of BHT and BHA on hepatoma induced by AFB_1 in rats. Exposure to AFB_1 alone induced a large number of transformed lesions. After 24 weeks of cessation of exposure, the incidence of liver cancer was 63%. Exposure of AFB_1 to BHT and BHA at the same time reduced conversion foci, and the incidence of hepatocellular carcinoma and the number of tumors in each animal also decreased in a dose-dependent manner.