肝纤维化是各种病因引起的慢性肝损害的共同病理结果,其过程是一个细胞外基质(extracellular matrix,ECM)合成与降解的动态过程,结果为ECM合成速度大于降解速度,造成ECM过度增多和异常沉积,多年来人们对ECM形成过程及机制进行了广泛深入地研究,而近年基质降解日益受到人们 Liver fibrosis is a common pathological result of chronic liver damage caused by various causes. The process is a dynamic process of the synthesis and degradation of extracellular matrix (ECM). As a result, the ECM synthesis rate is greater than the degradation rate, resulting in an over-ECM increase And abnormal deposition, ECM formation process and mechanism over the years have conducted extensive and in-depth study, and in recent years, matrix degradation is increasingly being people