近年来,对肿瘤与细胞周期深入研究,越来越清晰地认识到肿瘤是一类细胞周期疾病和细胞周期调控机制在肿瘤的侵袭、转移的过程中起着重要作用。细胞周期中最主要的调控点在G1～S转折和G2～M转折的DNA损伤关卡:①G1～S期关卡监控DNA是否损伤;②G2～M处的关卡监控DNA是否损伤及DNA是否正确、完全的复制,其分别控制DNA复制和细胞的有丝分裂。有许多基因和蛋白质参与调控细胞周期:①周期蛋 In recent years, in-depth study of the tumor and cell cycle, more and more clearly recognize that tumor is a class of cell cycle diseases and cell cycle regulatory mechanisms in tumor invasion and metastasis plays an important role. The most important cell cycle control points in the G1 ~ S transition and G2 ~ M turning point of DNA damage checkpoints: ① G1 to S level check the DNA damage; ② G2 ~ M at the checkpoint whether the DNA damage and DNA is correct, complete Replication, which controls DNA replication and cell mitosis, respectively. There are many genes and proteins involved in the regulation of the cell cycle: ① cycle of eggs