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5-脂氧合酶是5-脂氧合酶代谢通路中催化花生四烯酸转化为白三烯和氢氧化物的关键酶,在恶性肿瘤和多种病变细胞中高表达。它可以通过分裂原活化蛋白激酶激酶/细胞外信号调节激酶以及磷酯酰肌醇3激酶/蛋白激酶B等信号转导途径促进肿瘤细胞增殖,抑制肿瘤细胞凋亡。除此之外,5-脂氧合酶还可通过多种方式调控呼吸系统、消化系统以及循环系统等病变细胞的增殖与凋亡。
5-lipoxygenase is a key enzyme that catalyzes the conversion of arachidonic acid into leukotrienes and hydroxides in the 5-lipoxygenase metabolic pathway and is highly expressed in malignant tumors and various diseased cells. It can promote tumor cell proliferation and inhibit tumor cell apoptosis through the signal transduction pathways such as mitogen-activated protein kinase kinase / extracellular signal-regulated kinase and phosphatidylinositol 3-kinase / protein kinase B. In addition, 5-lipoxygenase can also regulate the proliferation and apoptosis of diseased cells such as the respiratory system, digestive system and circulatory system in a variety of ways.