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目的探讨不同年龄组胃癌患者的临床病理特征和预后。方法回顾性分析大连医科大学附属第一医院1995年1月至2004年12月行手术治疗的1526例胃癌患者的临床资料,按不同年龄段将患者分为3组,A组:≤40岁,B组:40岁～70岁,C组:≥70岁。对全组和各分组的临床病理特征和预后等情况做统计分析。结果全组患者中男性患者占多数,临床表现以不同程度的腹痛和腹胀及腹部不适多见。胃癌的好发部位以胃窦多见。全组早期胃癌约10.6%,Borrmann分型中以Ⅲ型多见,病理学检查以低/未分化为主,TNM分期全组以Ⅲ期和Ⅳ期多见,手术切除率全组为96.4%。随着患者年龄的增长,术后并发症和死亡率也增加。各组间生存率比较经Logrank检验,差异无显著性。结论各年龄组胃癌患者在性别分布、临床表现、病理类型、手术并发症及围手术期死亡率有差异,在肿瘤的发生部位、大小、Borrmann分型、TNM分期、早期诊断、手术切除率及生存率方面无明显差异。因此,行手术治疗的各年龄组胃癌患者的预后无明显差异,手术及早期诊断是决定胃癌患者预后的重要因素。
Objective To investigate the clinicopathological features and prognosis of gastric cancer patients of different age groups. Methods The clinical data of 1526 gastric cancer patients who underwent surgery from January 1995 to December 2004 in the First Affiliated Hospital of Dalian Medical University were retrospectively analyzed. The patients were divided into three groups according to different age groups: group A: ≤40 years old, Group B: 40 years old to 70 years old, Group C: ≥70 years old. The whole group and each group of clinicopathological features and prognosis and other statistical analysis. Results The majority of male patients in all patients accounted for the majority of clinical manifestations with varying degrees of abdominal pain and abdominal distension and more common. Stomach cancer is more common to the antrum. The early gastric cancer was about 10.6% in the group. Borrmann type was more common in type Ⅲ and low / undifferentiated in the pathological examination. The TNM stage was more common in stage Ⅲ and Ⅳ. Surgical resection rate was 96.4% . As the patient’s age increases, postoperative complications and mortality also increase. The survival rate between groups by Logrank test, the difference was not significant. Conclusion There are differences in gender distribution, clinical manifestations, pathological types, surgical complications and perioperative mortality in all age groups. The location, size, Borrmann classification, TNM staging, early diagnosis, surgical resection rate, No significant difference in survival rate. Therefore, the surgical treatment of gastric cancer patients of all age groups no significant difference in prognosis, surgery and early diagnosis is an important factor in determining the prognosis of gastric cancer patients.