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AIM:To compare the outcome of hand sewing and stapling for anastomotic leakage after esophagectomy.METHODS:A rigorous study protocol was established according to the recommendations of the Cochrane Collaboration.An electronic database search,hand search,and reference search were used to retrieve all randomized controlled trials that compared hand-sewn and mechanical esophagogastric anastomoses.RESULTS:This study included 15 randomized controlled trials with a total of 2337 patients.The results revealed that there was no significant difference in the incidence of anastomotic leakage between the methods[relative risk(RR)=0.77,95%confidence interval(CI):0.57-1.04;P=0.09],but a subgroup analysis yielded a significant difference for the sutured layer and year of publication(P s<0.05).There was also no significant difference in the incidence of postoperative mortality(RR=1.52,95%CI:0.97-2.40;P=0.07).However,the anastomotic strictures rate was increased in the stapler group compared with the hand-sewn group(RR=1.45,95%CI:1.11-1.91;P<0.01)in the end-to-side subgroup,while the incidence of anastomotic strictures was decreased(RR=0.34,95%CI:0.16-0.76;P<0.01)in the side-to-side subgroup.CONCLUSION:The stapler reduces the anastomotic leakage rate compared with hand sewing.End-to-side stapling increases the risk of anastomotic strictures,but side-to-side stapling decreases the risk.
AIM: To compare the outcome of hand sewing and stapling for anastomotic leakage after esophagectomy. METHODS: A rigorous study protocol was established according to the recommendations of the Cochrane Collaboration. An electronic database search, hand search, and reference search were used to retrieve all randomized controlled trials that compared to hand-sewn and mechanical esophagogastric anastomoses .RESULTS: This study included 15 randomized controlled trials with a total of 2337 patients. The results revealed that there was no significant difference in the incidence of anastomotic leakage between the methods [relative risk (RR) = 0.77, 95% confidence interval (CI): 0.57-1.04; P = 0.09], but a subgroup analysis yielded a significant difference for the sutured layer and year of publication (Ps <0.05). There was also no significant difference in the incidence of postoperative mortality (RR = 1.52, 95% CI: 0.97-2.40; P = 0.07) .owever, the anastomotic strictures rate was increased in the stapler group compared with the hand-sewn group (RR = 0.45, 95% CI: 1.11-1.91; P <0.01) in the end-to-side subgroup, while the incidence of anastomotic strictures was decreased ; P <0.01) in the side-to-side subgroup .CONCLUSION: The stapler reduces the anastomotic leakage rate compared with hand sewing. End-to-side stapling increases the risk of anastomotic strictures, but side- to-side stapling decreases the risk.