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survivin是凋亡抑制蛋白家族的最新成员,1997年由耶鲁大学的Altieri等利用效应细胞蛋白酶受体-1 cDNA在人类基因组库中筛选并且分离出来。随着对survivin的深入研究,发现它与恶性肿瘤的发生发展及对放疗和化疗的不敏感性有着密
Survivin is the newest member of the apoptosis-inhibitory protein family, which was screened and isolated from the human genomic bank using effector cell protease receptor-1 cDNA by Yale University’s Altieri et al. With the in-depth study of survivin, we found that it has a close relationship with the occurrence and development of malignant tumors and the insensitivity to radiotherapy and chemotherapy