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黑质致密部多巴胺能神经元大量缺失是帕金森病(Ｐａｒｋｉｎｓｏｎｓｄｉｓｅａｓｅ,ＰＤ)的一个重要特征。近年来 ,研究者对ＰＤ的发病机制提出了兴奋性氨基酸 (ＥＡＡ)的神经毒性学说。中枢神经系统中的主要ＥＡＡ是谷氨酸 (ｇｌｕｔａｍａｔｅ,Ｇｌｕ) ,其受体分为两大类 :
A large number of dopaminergic neurons in the substantia nigra pars compacta is an important feature of Parkinson’s disease (PD). In recent years, researchers have put forward the neurotoxicity theory of excitatory amino acids (EAA) on the pathogenesis of PD. The main EAA in the central nervous system is glutamate (Glu), whose receptors fall into two major categories: