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目的探讨宫体注射卡前列素氨丁三醇对预防剖宫产产后出血的效果。方法选择具有产后出血高危因素行剖宫产的220例产妇为研究对象,将其随机分为观察组和对照组,对照组110例产妇采用术后常规宫体注射缩宫素、米索前列醇及垂体后叶素联合预防治疗。观察组110例产妇采用术后常规宫体注射缩宫素联合卡前列素氨丁三醇治疗,比较两组产妇的临床疗效和不良反应发生情况。结果观察组的贫血发生率为2.73%,产后出血率为7.27%,子宫切除率为0,对照组分别为13.64%、23.64%和7.27%,两组比较,差异有统计学意义(P<0.05)。观察组的第三产程时间和止血时间分别为(2.78±0.37)min和(15.38±3.33)min,对照组为(4.28±0.42)min和(38.03±4.56)min,两组比较,差异有统计学意义(P<0.05)。观察组术后2 h和24 h出血量分别为(240.31±17.91)ml和(343.37±22.36)ml,对照组为(335.29±23.21)ml和(459.32±26.48)ml,两组比较,差异有统计学意义(P<0.05)。观察组的血红蛋白含量为(105.21±7.32)g/L,对照组为(83.72±6.21)g/L,两组比较,差异有统计学意义(P<0.05)。观察组的不良反应发生率为4.55%,对照组为20.91%,两组比较,差异有统计学意义(P<0.05)。结论在剖宫产术后,宫体注射卡前列素氨丁三醇可有效预防产后出血,安全性高,临床疗效好。
Objective To investigate the effect of intragastric administration of carboprost trometamol on the prevention of postpartum hemorrhage. Methods A total of 220 maternal women with cesarean section who were at risk of postpartum hemorrhage were selected as the study subjects and randomly divided into observation group and control group. 110 maternal women in the control group were treated with conventional oxytocin, misoprostol And pituitrin combined prevention and treatment. In the observation group, 110 maternal women were treated with oxytocin combined with carboprost trometamol, and the clinical efficacy and adverse reactions of the two groups were compared. Results The incidence of anemia in observation group was 2.73%, the rate of postpartum hemorrhage was 7.27%, the rate of hysterectomy was 0, and the control group was 13.64%, 23.64% and 7.27% respectively. There was significant difference between the two groups (P <0.05 ). The duration of the third stage of labor and the time to stop bleeding in the observation group were (2.78 ± 0.37) min and (15.38 ± 3.33) min, respectively, and the control group was (4.28 ± 0.42) min and (38.03 ± 4.56) min respectively Significance (P <0.05). The amount of bleeding at 2 h and 24 h after operation in the observation group were (240.31 ± 17.91) ml and (343.37 ± 22.36) ml, respectively, and the control group was (335.29 ± 23.21) ml and (459.32 ± 26.48) ml respectively Statistical significance (P <0.05). The hemoglobin content of the observation group was (105.21 ± 7.32) g / L and that of the control group was (83.72 ± 6.21) g / L, the difference was statistically significant (P <0.05). The incidence of adverse reactions in the observation group was 4.55% and that in the control group was 20.91%. There was significant difference between the two groups (P <0.05). Conclusion After cesarean section, intrauterine injection of carboprost trometamol can effectively prevent postpartum hemorrhage with high safety and good clinical curative effect.