随着分子生物学技术的发展,对扩张型心肌病的分子遗传机制认识也在不断提高。ZASP(Z-band alternatively spliced PDZ-motif protein)基因即Z带选择性缝接PDZ基序蛋白基因,国外新近研究揭示了编码心肌肌小节Z带蛋白的ZASP基因突变对扩张型心肌病心肌细胞骨架成分构成及肌小节收缩功能的影响,但仍存在着一些不同的观点。现就ZASP基因的结构构成与导致扩张型心肌病的可能机制作一综述。 With the development of molecular biology technology, understanding of the molecular genetic mechanism of dilated cardiomyopathy is also increasing. ZASP (Z-band alternatively spliced ​​PDZ-motif protein) gene, ie, Z-band selective PDZ motif protein gene, recently foreign studies revealed that ZASP gene mutation encoding Z-band protein in cardiac myenteric nodules has a negative effect on dilatation cardiomyopathy Composition and muscle function of the contractions, but there are still some different views. The structure of ZASP gene and the possible mechanism leading to dilated cardiomyopathy are reviewed.