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本研究着重对吸入某些有代表性并大量使用的烃类毒性进行探讨;目的为制订各种石油烃的卫生标准及确认或修订现行卫生标准提供依据。早期研究重点局限于美国工业卫生工作者协会(ACGIH)阈限委员会所观察的烃类和混合物。本次选用的烃类所根据的参数为沸点范围和所含芳族化合物的百分比。本文提供了有广泛根据的资料,使有可能用这些参数来预计任何混合物的毒性。大鼠分别吸入各种浓度毒物4小时,求LC_(50)值,及损害机体的主要部位。选用吸入相当大鼠LC_(50)的浓度,以探索明显影响中枢神经系统的迹象。而后用
This study focused on the inhalation of some representative and widely used hydrocarbon toxicity; Objectives for the development of various petroleum hydrocarbon health standards and to confirm or amend the current health standards to provide the basis. Earlier research was limited to the hydrocarbons and mixtures observed by the ACGIH Threshold Committee. The parameters for this selection of hydrocarbons are based on the boiling point range and the percentage of aromatics contained. This article provides a broad base of evidence that makes it possible to predict the toxicity of any mixture with these parameters. Rats were inhaled various concentrations of poisons for 4 hours, seek LC_ (50) value, and damage the body parts. Inhalation of LC_ (50) in rats was used to explore signs of significant CNS effects. Then use