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临床上见到同年龄男女组冠状动脉硬化病例中,男性较女性重。有大量统计资料证实,冠心病尤其是心肌梗塞,男性远较女性多见,中年期尤为明显.经过近一个世纪研究,冠心病与血脂关系已基木明确.近20年来的研究认为,性激素与冠心病的发生有关,但其关系及作用原理不明.如Robinson 在102例45岁前作了双侧卵巢及子官切除者和112例仅作子宫切除者对照,观察时间是术后12年,见到前一组发生冠状血管病变、心绞痛、心肌梗塞等均较后者多.血清总胆固醇(TC)及低密度脂蛋白-胆同醇(LDL-C),前组均有增加,而后者无改变.另有学者(Aitkcn ct al)研究认为雌激素能使血脂降低,绝经后(自然绝经或人工绝经)妇女雌激素低落.致冠心病的发生有所增加。Olivcr 的研究资
Clinically to see the same age group of men and women coronary atherosclerosis cases, men than women. A large number of statistical data confirmed that coronary heart disease, especially myocardial infarction, more common in men than women, especially in middle age.After nearly a century of research, coronary heart disease and blood lipids have been clearly defined.Researches of the past 20 years, sex hormones And the occurrence of coronary heart disease, but the relationship and the principle of unknown.As Robinson in 102 cases of 45 years before the age of 45 were bilateral ovarian and subtotal resection and 112 cases only for hysterectomy control, the observation time is 12 years after surgery, Coronary angiopathy, angina pectoris and myocardial infarction were seen in the former group more than the latter.Serum total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) Another study by Aitkacn ct al suggests that estrogen decreases blood lipids and low estrogen levels in postmenopausal women (natural menopause or artificial menopause), leading to an increase in coronary heart disease. Olivcr research funding