目的复发难治血小板减少性紫癜(ITP)目前仍是血液科医生治疗的难题,特别是脾切后复发者,观察大剂量甲泼尼龙联合硫唑嘌呤的疗效。方法 2例脾切后复发 ITP,1例男性,20岁;1例女性,27岁,都曾用大剂量丙球联合泼尼松治疗失败。复发时血小板计数分别为:5×10~9/L 和8×10~9/L。治疗方法:甲泼尼龙0.5 g第1～3天,40 mg,移 Objective Recurrence refractory thrombocytopenic purpura (ITP) is still a hematologist treatment problems, especially those who relapse after splenectomy to observe the effect of high-dose methylprednisolone combined with azathioprine. Methods Two cases of ITP after splenectomy were recurred. One male, 20 years old, and one female, aged 27 years, had failed the treatment with high-dose corticosteroid plus prednisone. The platelet counts at recurrence were 5 × 10 ~ 9 / L and 8 × 10 ~ 9 / L, respectively. Treatment: methylprednisolone 0.5 g 1 to 3 days, 40 mg, shift