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以透皮吸收模型观察了剂型及温度对双氯灭痛透皮吸收的影响。结果表明,搽剂中双氯灭痛的透皮吸收量远高于膏剂;45℃孵温能显著加快双氯灭痛的透皮吸收。
The effects of dosage form and temperature on transdermal absorption of diclofenac sodium were observed by transdermal absorption model. The results showed that the percutaneous absorption of diclofenac in liniment was much higher than that of the ointment. Incubation at 45 ℃ significantly accelerated the transdermal absorption of diclofenac.