近年来,开展神经内分泌免疫调节网络(NEI)的研究日趋广泛,已知糖皮质激素(GC)在其中起重要作用。淋巴细胞足GC的靶细胞之一,GC必须通过和靶细胞中糖皮质激素受体(GCR)结合,才能发挥生物效应。现在通用的淋巴细胞中GCR的测定方法是1ml反应体系的离心分离法,我们以研究NEI常用的大鼠为实验对象,对其方法进行了改进,采用微量过滤法,比较经济、简便、适用。 In recent years, research on neuroendocrine immune regulatory network (NEI) is becoming more and more widespread. Glucocorticoid (GC) is known to play an important role. One of the target cells for lymphoid GC, GC must exert a biological effect by binding to the glucocorticoid receptor (GCR) in target cells. GCR now commonly used in lymphocyte measurement method is 1ml reaction system centrifugation method, we used to study the NEI rats used as experimental subjects, the method was improved, the use of microfiltration method, more economical, simple and suitable.