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为研究高胆固醇膳食诱发兔胆囊胆固醇结石模型的脂代谢变化，以及高密度脂蛋白（ＨＤＬ）对其脂代谢及成石的影响，将动物随机分为对照组、高胆固醇膳食组及高胆固醇膳食＋ＨＤＬ注射组，观察各组血浆脂质、胆汁中胆固醇、血卵磷脂胆固醇酰基转移酶（ＬＣＡＴ）活性及血和胆汁中胆汁酸及成石率的变化。结果显示：动物体内胆固醇等脂质的消除障碍导致体内脂质的大量堆积以及清除紊乱，是高胆固醇膳食诱发兔胆囊结石脂代谢变化的主要特点，胆汁中胆固醇与胆汁酸的清除比例失调可能导致成石性胆汁形成；尽管外源性ＨＤＬ制剂能够升高血浆ＨＤＬ２－Ｃ／ＨＤＬ３－Ｃ的比值，增加ＬＣＡＴ的活性从而促使ＨＤＬ成熟，并能降低肝脏的胆固醇含量，但未能降低成石率。结果表明外源性ＨＤＬ制剂对兔胆囊结石形成中脂代谢有一定的影响，但抗成石作用不明显
In order to study the changes of lipid metabolism in cholesterol gallstone-induced cholesterol gallstone model and the effect of high density lipoprotein (HDL) on lipid metabolism and stone formation, the animals were randomly divided into control group, high cholesterol diet group and high cholesterol diet + HDL injection group to observe the changes of plasma lipid, bile cholesterol, blood lecithin cholesterol acyltransferase (LCAT) activity and bile acid and stone forming rate in blood and bile. The results showed that: the removal of cholesterol and other lipid in animals lead to a large number of accumulation and clearance of lipid in the body, which is the main characteristic of the cholesterol metabolism induced by cholesterol in the gallbladder. The unbalanced clearance of cholesterol and bile acid in bile may lead to Into the formation of stone bile; Although exogenous HDL preparation can increase plasma HDL2-C / HDL3-C ratio, increase LCAT activity to promote the HDL mature, and can reduce the liver cholesterol content, but failed to reduce the rate of stone . The results show that exogenous HDL preparation of rabbit gallstone formation in the lipid metabolism have a certain impact, but anti-stone effect was not obvious