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利福平(RFP)是肝脏药物代谢氧化酶的诱导物。肝活检标本证明:接受RFP的患者有细胞血素P_(450)的增加和肝细胞内浆网的增生。连续应用RFP治疗期间由于药物本身的代谢可缩短其半寿期。此外RFP可以加速避孕药、甲苯磺丁脲、环已烯巴比土、口服抗凝剂等药物的排出。 作者通过2例患者(1例为类风湿性关节炎引起的间质性肺炎伴纤维化肺泡炎,另1例为结节病)进行了临床观察。此2例开始均因诊断未确而
Rifampicin (RFP) is an inducer of hepatic drug-metabolizing oxidases. Liver biopsy specimens demonstrated that patients receiving RFP had an increase in P 450 and an increase in reticuloendotheliosis in hepatocytes. Continuous application of RFP during treatment due to the metabolism of the drug itself can shorten its half-life. In addition, RFP can accelerate the discharge of contraceptives, tolbutamide, cyclohexenebarbadi, oral anticoagulants and other drugs. The authors performed clinical observations in 2 patients (1 with interstitial pneumonia associated with fibrosis alveolitis due to rheumatoid arthritis and 1 with sarcoidosis). The two cases were not diagnosed because of the diagnosis