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目的:观察坤泰胶囊联合激素治疗阴虚型卵巢早衰的临床疗效,及对患者血清性激素和血脂指标的影响。方法:选取82例阴虚型卵巢早衰患者,按照随机数字表法分为对照组与观察组各41例。对照组采用激素替代疗法治疗,观察组在对照组用药基础上联合坤泰胶囊治疗。2组均以4周为1疗程,连续治疗3疗程。结果:观察组治疗总有效率90.24%,高于对照组的68.29%(P<0.05)。治疗后,2组血清黄体生成激素(LH)、卵泡刺激素(FSH)水平均较治疗前降低(P<0.05),雌二醇(E2)水平均较治疗前升高(P<0.05);观察组的血清LH、FSH水平均低于对照组(P<0.05),E2水平高于对照组(P<0.05)。治疗后,2组甘油三酯(TG)、总胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)水平均较治疗前降低(P<0.05),高密度脂蛋白胆固醇(HDL-C)水平均较治疗前升高(P<0.05);观察组的TG、TC、LDL-C水平均低于对照组(P<0.05),HDL-C水平高于对照组(P<0.05)。治疗期间,对照组不良反应发生率21.95%,观察组不良反应发生率2.44%,2组比较,差异有统计学意义(P<0.05)。结论:坤泰胶囊联合激素治疗阴虚型卵巢早衰,可有效改善患者的临床症状、血清性激素和血脂指标,临床疗效优于单纯使用激素替代疗法,且安全性相对较高。
Objective: To observe the curative effect of KunTai capsule combined with hormones in treatment of yin deficiency type of premature ovarian failure and its effect on serum sex hormones and serum lipids. Methods: 82 cases of Yin-type premature ovarian failure were divided into control group and observation group according to the random number table method in 41 cases. The control group was treated with hormone replacement therapy. The observation group was treated with Kuntai capsule on the basis of the control group. 2 groups were 4 weeks for a course of treatment, continuous treatment of 3 courses. Results: The total effective rate of observation group was 90.24%, higher than that of control group (68.29%, P <0.05). After treatment, the levels of serum LH and FSH in both groups were lower than those before treatment (P <0.05) and the levels of estradiol (E2) were higher than those before treatment (P <0.05). The levels of serum LH and FSH in the observation group were lower than those in the control group (P <0.05), and the levels of E2 in the observation group were higher than those in the control group (P <0.05). After treatment, the levels of triglyceride (TG), total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in two groups were lower than those before treatment (P < (P <0.05). The levels of TG, TC and LDL-C in the observation group were lower than those in the control group (P <0.05), and the levels of HDL-C in the observation group were higher than those in the control group (P <0.05). The incidence of adverse reactions in the control group was 21.95% during the treatment period, and the incidence of adverse reactions in the observation group was 2.44%. There was significant difference between the two groups (P <0.05). Conclusion: Kuntai capsule combined with hormone treatment of yin deficiency type of premature ovarian failure can effectively improve the clinical symptoms, serum sex hormones and blood lipids, clinical efficacy is better than the simple use of hormone replacement therapy, and the safety is relatively high.