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目的评价盐酸地尔硫卓(合贝爽)注射剂在治疗高龄老年重症高血压中的有效性和安全性。方法收集上海市松江区泗泾医院60例年龄≥70岁,合并有高血压的患者,随机分为观察组与对照组。观察组30例,2 h内静脉注射合贝爽1~40μg/kg.min速度维持静滴;对照组30例,2 h内静脉注射硝酸甘油5~100μg/kg.min速度静滴。测定两组用药前、2 h后心电图,观察心率(HR)、ST-T、SBP、DBP。结果治疗后观察组与对照组的血压均与治疗前比较差异有统计学意义(P<0.01)。治疗后观察组HR与治疗前比较有非常显著下降(P<0.01)。观察组有1例出现一过性心动过缓,调整输液速度后消失,未有严重低血压或心功能不全。对照组有6例出现头昏、发胀、心慌,5例有明显头痛,其中2例不能耐受停止治疗。两组较治疗前ST-T改善,但差异无统计学意义,无严重低血压和心功能不全。结论合贝爽治疗高龄老年重症高血压的疗效确切,起效较快,安全,不良反应少。
Objective To evaluate the efficacy and safety of diltiazem hydrochloride injection in the treatment of senile patients with severe hypertension. Methods Sixty patients (≥70 years old, with hypertension) in Sijing Hospital of Songjiang District of Shanghai were randomly divided into observation group and control group. In the observation group, 30 patients were treated with intravenous injection of bupolam at a speed of 1 ~ 40μg / kg · min within 2 hours, while those in the control group were intravenously administered with nitroglycerin at a dose of 5-100 μg / kg.min within 2 hours. The electrocardiogram (ECG), heart rate (HR), ST-T, SBP and DBP were measured before and 2 h after treatment. Results After treatment, the blood pressure of observation group and control group were significantly different from those before treatment (P <0.01). After treatment, HR in observation group was significantly lower than that before treatment (P <0.01). One patient in the observation group had transient bradycardia, disappeared after adjusting infusion speed, and had no severe hypotension or cardiac insufficiency. In the control group, 6 patients experienced dizziness, bloating and palpitation. Five patients had obvious headache, of which 2 patients were unable to tolerate stop treatment. Both groups improved ST-T before treatment, but the difference was not statistically significant, without severe hypotension and cardiac insufficiency. Conclusion Hebeiphon treatment of senile elderly patients with severe hypertension is effective, rapid onset, safety, adverse reactions.