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目的对比分析不同剂量参附注射液联合左卡尼汀治疗老年慢性心力衰竭(CHF)的疗效差异。方法选择于2014年3月~2015年12月在入住本院的老年CHF患者142例,随机分为参附50 ml组(47例)、参附100 ml组(48例)和对照组(47例)。所有患者均接受常规抗心衰药物治疗及左卡尼汀2 g/d,参附50 ml组再给予参附注射液50 ml/d,参附100 ml组给予参附注射液100 ml/d,14 d为1个疗程。比较3组治疗前及治疗后的NYHA心功能分级和Lee氏心衰积分、心功能、血N末端脑钠肽前体(NT-proBNP)、生活质量评分及6分钟步行试验(6MWT)的差异。结果参附100 ml组患者的NYHA心功能分级、Lee氏心衰积分、左室射血分数、心肌做功指数、NT-proBNP、生存治疗和6MWT改善较另外两组患者的更显著(P<0.05);参附100 ml组的临床显效率及总有效率也高于另外两组。结论对于老年CHF患者,参附注射液联合左卡尼汀疗效确切,大剂量参附注射液联合左卡尼汀疗效更好。
Objective To compare the curative effects of different doses of Shenfu injection and levocarnitine in elderly patients with chronic heart failure (CHF). Methods A total of 142 elderly CHF patients admitted to our hospital from March 2014 to December 2015 were randomly divided into the treatment group (n = 50) and the control group (n = 47) example). All patients received routine anti-heart failure drug treatment and levocarnitine 2 g / d, with reference to 50 ml group were given Shenfu injection 50 ml / d, Shenfu 100 ml group given Shenfu injection 100 ml / d , 14 d for a course of treatment. The difference of NYHA functional class, Lee’s heart failure index, heart function, NT-proBNP, QOL and 6MWT before and after treatment were compared . Results Compared with the other two groups, NYHA functional class, Lee’s heart failure score, left ventricular ejection fraction, myocardial work index, NT-proBNP, survival treatment and 6MWT improved significantly ). The clinical effective rate and total effective rate of Shenfu 100 ml group were also higher than the other two groups. Conclusion For elderly patients with CHF, Shenfu injection combined with levocarnitine has the exact effect, and high dose Shenfu injection combined with levocarnitine has a better effect.