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目的探讨在急性呼吸窘迫综合征(ARDS)血浆中脑肽钠(BNP)及内皮素(ET)水平的动态变化。方法采用放射免疫法测定30例急性呼吸窘迫综合征患者1d、3d、5d、7d与健康对照组静脉血中BNP、ET水平。结果急性呼吸窘迫综合征在发病后1、3、5、7d,患者血浆BNP、ET含量发生明显变化。血浆BNP含量分别为(125±30),(123±28),(130±33),(139±36)ng/L;ET水平分别为(168±26)(167±30),(171±32),(183±37)ng/L。结论急性呼吸窘迫综合征血浆BNP、ET水平明显升高,BNP和ET参与了急性呼吸窘迫综合征病理生理过程,其含量的变化可能与疾病的发展有关。
Objective To investigate the dynamic changes of plasma brain natriuretic peptide (BNP) and endothelin (ET) in patients with acute respiratory distress syndrome (ARDS). Methods The levels of BNP and ET in venous blood of 30 patients with acute respiratory distress syndrome were measured by radioimmunoassay at 1d, 3d, 5d, 7d and healthy controls. Results In patients with acute respiratory distress syndrome at 1, 3, 5 and 7 days after onset, the levels of plasma BNP and ET significantly changed. Plasma BNP levels were (125 ± 30), (123 ± 28), (130 ± 33) and (139 ± 36) ng / L, respectively 32), (183 ± 37) ng / L. Conclusions The levels of BNP and ET in plasma of patients with acute respiratory distress syndrome are significantly elevated. BNP and ET are involved in the pathophysiological process of acute respiratory distress syndrome, and their changes may be related to the development of the disease.