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氧化应激是糖尿病肾病的重要发病机制之一。近年来氧化低密度脂蛋白(Ox-LDL)在糖尿病肾病发生、发展上的作用越来越受到关注,再度成为研究热点。本文综述了近年来关于Ox-LDL的形成及代谢机制、糖尿病肾病进展中Ox-LDL的变化及其临床意义,以及针对Ox-LDL一些新的治疗措施,以进一步理解Ox-LDL在糖尿病肾病发病、进展机制上的作用,为临床有效治疗糖尿病肾病提供新思路。
Oxidative stress is one of the important pathogenesis of diabetic nephropathy. In recent years, the role of Ox-LDL in the occurrence and development of diabetic nephropathy has drawn more and more attention and once again become a research focus. This review summarizes the recent advances in the formation and metabolism of Ox-LDL, Ox-LDL in diabetic nephropathy and its clinical significance, as well as some new treatments for Ox-LDL to further understand the role of Ox-LDL in the pathogenesis of diabetic nephropathy , The role of progress mechanism for the clinical treatment of diabetic nephropathy to provide new ideas.