连接黏附分子C(JAM-C)是近几年来研究逐渐增多的一种免疫球蛋白。JAM-C的分子结构、分布及其与特定配体作用的特点,决定了JAM-C在精子的形成、调节细胞旁通透性、调节白细胞的游走、调节血管的发生和肿瘤的增长、转移等多种生理、病理过程中起到了极其重要的作用,也对相关疾病的诊断及治疗提供了新的研究方向。现就JAM-C的分布表达、病理生理作用、与相应疾病的关系以及其可能作为未来疾病治疗的靶点予以综述。 The adhesion molecule C (JAM-C) is an immunoglobulin that has been studied in recent years. JAM-C molecular structure, distribution and the role of specific ligands determine the JAM-C in the formation of sperm, regulating cell paracellular permeability, regulating leukocyte migration, regulating the occurrence of blood vessels and tumor growth, Metastasis and other physiological and pathological processes play an extremely important role, but also for the diagnosis and treatment of related diseases provides a new research direction. Now on the distribution of JAM-C expression, the role of pathophysiology, and the relationship between the disease and its potential as the future treatment of disease targets are reviewed.