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目的:探讨千里香不同提取部位(水、氯仿、乙酸乙酯)对大鼠离体肠运动功能和小鼠胃排空、小肠推进运动功能的抑制作用。方法:采用大鼠离体回肠自发运动实验和乙酰胆碱所致大鼠离体回肠痉挛性收缩实验,观察千里香各提取部位抑制离体肠运动功能的作用;采用小鼠胃排空和小肠推进运动实验,观察千里香各提取部位抑制在体胃、肠运动功能作用。结果:千里香水提部位、氯仿部位和乙酸乙酯部位对大鼠离体回肠自发运动以及乙酰胆碱所致大鼠离体回肠痉挛性收缩均具有显著抑制作用;乙酸乙酯部位能显著抑制小鼠胃排空和小肠推进率,氯仿部位能显著抑制小鼠胃排空,而水提部位对小鼠胃排空和小肠推进率则无显著影响。结论:千里香水提部位、氯仿部位、乙酸乙酯部位均具有一定的抑制胃肠运动功能的作用,其中乙酸乙酯部位作用较强。
OBJECTIVE: To investigate the inhibitory effects of different extracts of Tricholoma. (Water, chloroform and ethyl acetate) on intestinal motility in vitro and gastric emptying and intestinal motility in mice. Methods: The isolated rat ileum spontaneous exercise test and acetylcholine-induced ileal spastic contraction in rats were observed Tricholoma role in inhibiting intestinal motility in vitro extracts; gastric emptying and intestinal propulsion Experiments were conducted to observe the effects of various parts of Tricholoma pallidum in inhibiting the function of stomach and intestine. Results: The extract of Trillium, Chloroform and Ethyl Acetate had significant inhibitory effects on the spontaneous ileum movement in isolated rat and the isolated ileal spastic contraction induced by acetylcholine in rats. Ethyl acetate could significantly inhibit the gastric Emptying and intestinal propulsion rate, chloroform site can significantly inhibit gastric emptying in mice, and water extraction site on gastric emptying and intestinal propulsion rate was no significant effect. CONCLUSION: The extract of Trillium, chloroform and ethyl acetate all have certain effect of inhibiting gastrointestinal motor function, and the effect of ethyl acetate is stronger.