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目前批准的人用鼠疫疫苗为全菌体灭活疫苗 ( KWCV) ,需要多次加强才能建立和维持适当的免疫 ,且有明显的短暂副反应。作者用鼠疫杆菌的 F1和 V抗原 ,制备了鼠疫亚单位疫苗 ,并就其免疫原性和保护力与KWCV进行比较。 将源于鼠疫杆菌培养上清的 F1抗原与源于大肠杆菌裂解物的
The currently approved human plague vaccine is a whole cell inactivated vaccine (KWCV) that needs to be multiplied several times to establish and maintain appropriate immunity with significant transient side effects. The authors used the Yersinia pestis F1 and V antigens to prepare a subunit vaccine and compared its immunogenicity and protective ability against KWCV. The F1 antigen derived from the Y. pestis culture supernatant was mixed with the E. coli lysate