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小儿出生后一周内,当其血清胆红素浓度超过10～15毫克%时,即称为新生儿高胆红素血症。本病的主要危害是由于血内间接胆红素浓度增高,透过血脑屏障,与脑神经细胞结合而导致核黄疸。一般认为,当血清胆红素浓度达到18～20毫克%时,即可能发生核黄疸。其浓度愈高,发生核黄疸的可能性愈大。未成熟儿对此更为敏感,当其血清胆红素浓度超过10毫克%时,即可能导致核黄疸。核黄疸的预后严重,病死率很高,即使患儿幸免死亡,亦常留下神经系统严重后遗症。此外,如未成熟儿的血清胆红
Within one week after birth, when the serum bilirubin concentration exceeds 10 ~ 15 mg%, it is called neonatal hyperbilirubinemia. The main hazard of this disease is due to increased blood concentration of indirect bilirubin, through the blood-brain barrier, combined with the brain cells leading to nuclear jaundice. It is generally believed that when the serum bilirubin concentration of 18 to 20 mg%, kernicterus may occur. The higher the concentration, the greater the likelihood of occurrence of nuclear jaundice. Immature children are more sensitive to this, when the serum bilirubin concentration exceeds 10 mg%, which may lead to nuclear jaundice. The prognosis of kernicterus is serious and the case fatality rate is very high. Even if the child survives the death, it often leaves serious sequelae of the nervous system. In addition, such as immature children serum bilirubin