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目的探讨小儿反复呼吸道感染(RRI)与头发中微量元素锌含量的关系。方法选择婴幼儿反复呼吸道感染且血锌值低于正常的门诊患儿60例,随机分成观察组、对照组各30例。对照组采用常规治疗,观察组在常规治疗的基础上,每日餐后口服葡萄糖酸锌片3.5 mg/kg,治疗后检查患儿血清免疫球蛋白IgA、IgG、IgM,并根据血清锌水平进行分析。结果治疗后观察组RRI患儿血清Zn明显高于对照组(P<0.05);对照组RRI患儿血清IgGI、gA明显低于对照组(P均<0.05),而IgM在两组间差异无统计学意义(P>0.05);治疗结束1年内,观察组呼吸道感染发病率明显低于对照组,无毒副作用。结论锌对反复呼吸道感染有一定的疗效,值得推广。
Objective To investigate the relationship between RRI in children and the content of zinc in hair. Methods Sixty children diagnosed as recurrent respiratory tract infection with lower blood zinc level in infants and young children were randomly divided into observation group (30 cases) and control group (30 cases). In the control group, conventional treatment was used. On the basis of routine treatment, the observation group was given 3.5 mg / kg zinc gluconate daily after meals. Serum immunoglobulin IgA, IgG and IgM in children were examined after treatment and were determined according to serum zinc levels analysis. Results After treatment, serum Zn of RRI children in observation group was significantly higher than that in control group (P <0.05). Serum IgGI and gA in RRI children in control group were significantly lower than those in control group (P <0.05) Statistical significance (P> 0.05); within one year after the end of treatment, the incidence of respiratory tract infection in the observation group was significantly lower than that of the control group, with no toxic or side effects. Conclusion Zinc has a certain curative effect on recurrent respiratory tract infections and is worth promoting.