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目的探讨尼莫地平对高血压并腔隙性脑梗死患者神经功能、患侧脑血流速度及预后的影响。方法选取2014年5月—2016年4月资阳市第四人民医院收治的高血压并腔隙性脑梗死患者55例,采用随机数字表法分为对照组22例和观察组23例。对照组患者给予胞磷胆碱治疗,观察组在此基础上给予尼莫地平治疗;两组患者均连续治疗14 d。比较两组患者神经功能缺损程度评分、患侧脑血流速度及临床疗效。结果两组患者治疗前神经功能缺损程度评分比较,差异无统计学意义(P>0.05);观察组患者治疗后神经功能缺损程度评分低于对照组(P<0.05)。两组患者治疗前患侧基底动脉(BA)、大脑中动脉(MCA)、大脑前动脉(ACA)的收缩期最大血流速度比较,差异无统计学意义(P>0.05);观察组患者治疗后患侧BA、MCA、ACA的收缩期最大血流速度高于对照组(P<0.05)。观察组患者临床疗效优于对照组(P<0.05)。结论尼莫地平可有效改善高血压并腔隙性脑梗死患者神经功能和患侧脑血流速度,提高临床疗效。
Objective To investigate the effect of nimodipine on neurological function, cerebral blood flow velocity and prognosis in patients with hypertension and lacunar infarction. Methods From May 2014 to April 2016, 55 patients with hypertension and lacunar infarction in Ziyang No.4 People’s Hospital were divided into control group (n = 22) and observation group (n = 23) by random number table. Control group patients were given citicoline treatment, the observation group on the basis of nimodipine treatment; two groups of patients were treated for 14 days. The scores of neurological deficit, cerebral blood flow velocity and clinical curative effect were compared between the two groups. Results There was no significant difference in scores of neurological deficits between the two groups before treatment (P> 0.05). The score of neurological impairment in the observation group was lower than that of the control group after treatment (P <0.05). There was no significant difference in the maximum systolic blood flow velocity between the two groups before treatment in patients with BA, MCA, ACA (P> 0.05). The treatment group The maximum systolic blood flow velocity of the affected side BA, MCA and ACA was higher than that of the control group (P <0.05). The clinical efficacy of the observation group was better than that of the control group (P <0.05). Conclusion Nimodipine can effectively improve the neurological function and cerebral blood flow velocity in patients with hypertension and lacunar infarction, and improve the clinical curative effect.