论文部分内容阅读
第三类氯霉素与合霉素氯霉素为广谱抗菌素、合霉素是人工合成的含右旋异构体与左旋异构体各一半,其中左旋异构体的抗菌效能和氯霉素相同。氯霉素对肠道细菌敏感,但近年来耐氯霉素的痢疾杆菌与伤寒杆菌在增长。它对肺炎球菌、溶血性链球菌、脑膜炎球菌、草绿色链球菌、白喉杆菌、百日咳杆菌、流感杆菌与立克次体也很敏感。氯霉素可口服、肌注与静滴。口服后吸收很快而且完全,吸收后弥散进许多组织,可透入眼睛的各部分,能透入正常脑脊液、胸水、腹水及胎盘。正常脑脊液中氯霉素浓度是血清浓度的一半,是常用抗菌素中透人脑脊液含量
Chloramphenicol and coenomycin chloramphenicol are broad-spectrum antibiotics. Synthomycin is one half of the synthetic dextrorotatory and levorotatory isomers. Among them, The same is true. Chloramphenicol is sensitive to intestinal bacteria, but in recent years resistant to chloramphenicol Shigella and Salmonella typhi growth. It is also very sensitive to pneumococci, hemolytic streptococci, meningococci, Streptococcus viridans, diphtheria bacilli, Bordetella pertussis, flu bacilli and rickettsia. Chloramphenicol can be oral, intramuscular and intravenous infusion. Absorbed quickly and completely after oral absorption absorbed into many organizations, can penetrate the various parts of the eye, can penetrate the normal cerebrospinal fluid, pleural effusion, ascites and placenta. Chloramphenicol concentration in normal cerebrospinal fluid is half of serum concentration, is commonly used in human cerebrospinal fluid levels of antibiotics