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目的了解2型糖尿病患者下肢血管病变(PVD)发生率,分析PVD的相关危险因素。方法对2000~2003年在浙江大学医学院附属第一医院内分泌科住院治疗297例2型糖尿病患者进行回顾性分析(单因素及Logistic回归分析)。结果64.98%(193/297)患者多普勒超声检查提示有下肢血管病变。年龄、病程、24h尿白蛋白(UAE)、血尿酸(UA)、血肌酐(Cr)、收缩压增高比例、周围神经病变(DPN)比例、冠心病(CHD)比例在有下肢血管病变者中均显著增高(P<0.01)。Logistic回归分析结果表明,年龄、总胆固醇(Tch)、DPN是PVD的独立危险因素(OR=1.087,1.353,2.201)。结论2型糖尿病患者下肢血管病变发生率高,与年龄、血脂、血压、血糖以及糖尿病其它慢性并发症多种因素相关。
Objective To investigate the incidence of lower extremity vascular lesions (PVD) in type 2 diabetic patients and analyze the related risk factors of PVD. Methods A retrospective analysis was performed on 297 type 2 diabetic patients admitted to Department of Endocrinology, First Affiliated Hospital of Zhejiang University from 2000 to 2003 (single factor and Logistic regression analysis). Results 64.98% (193/297) of patients with Doppler ultrasound showed lower extremity vascular lesions. Age, course of disease, urinary albuminuria (UAE), serum uric acid (UA), serum creatinine (Cr), increased systolic blood pressure, ratio of peripheral neuropathy (DPN) and coronary heart disease (CHD) Were significantly higher (P <0.01). Logistic regression analysis showed that age, total cholesterol (Tch) and DPN were independent risk factors of PVD (OR = 1.087,1.353,2.201). Conclusions The incidence of lower extremity vascular lesions in patients with type 2 diabetes is high and related to various factors such as age, blood lipid, blood pressure, blood glucose, and other chronic complications of diabetes.