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目的探讨三维适形放射治疗宫颈癌复发患者的临床疗效与不良反应。方法选取子宫颈癌治疗后复发患者60例,以直线加速器6mv-x线行三维适形放疗,单次剂量2~2.2Gy,每日1次,每周5次,总剂量56~60Gy,平均剂量58.5Gy。结果阴道出血缓解率100%,腰腿疼痛缓解率达100%,患侧下肢水肿缓解率67%,肿瘤治疗有效(CR+PR)率为76.7%(46/60),1和3年生存率分别为38%和13%,中位生存时间18个月。放射性肠炎近期反应发生率为8.3%;放射性膀胱炎近期反应发生率为3.3%,骨髓抑制(Ⅰ度)发生率为10%,放射性肠炎远期并发症发生率6.7%,放射性膀胱炎远期并发症发生率为5%。结论三维适形放疗效治疗复发性子宫颈癌疗效较好,放疗并发症少,不良反应小。
Objective To investigate the clinical efficacy and adverse reactions of three-dimensional conformal radiotherapy in patients with recurrent cervical cancer. Methods Sixty patients with recurrence of cervical cancer were treated with three-dimensional conformal radiotherapy with a linear accelerator 6mv-x. The single dose was 2 ~ 2.2 Gy, once daily, 5 times a week, with a total dose of 56-60 Gy, with an average of Dose 58.5 Gy. Results The rate of response to vaginal bleeding was 100%, the pain relief rate of lumbar and leg was 100%, the relief rate of ipsilateral lower extremity edema was 67%, the rate of CR + PR was 76.7% (46/60), the 1-year and 3-year survival rates Respectively, 38% and 13%, the median survival time of 18 months. The recent incidence of radioactive enteritis was 8.3%; recent incidence of radioactive cystitis was 3.3%, bone marrow suppression (Ⅰ degree) was 10%, long-term complications of radiation enteritis 6.7%, long-term radiation cystitis The incidence of disease is 5%. Conclusion Three-dimensional conformal radiotherapy is effective in treating recurrent cervical cancer with less radiotherapy complications and less adverse reactions.