论文部分内容阅读
目的:分析异基因造血干细胞移植后肺炎的临床特点和病因谱。方法:总结北京大学血液病研究所1998至 2001连续 4年中 255例异基因造血干细胞移植受者中发生移植后肺炎的资料。结果: 66例发生移植后肺炎的患者累计发病 72例次,总发病率 25. 9%; 50例患者的移植后肺炎被治愈,占 75%。病因分析显示,细 /真菌感染性移植后肺炎 12例次(16. 7% ),巨细胞病毒性肺炎 22例次(30. 6% ),特发性肺炎综合征 36例次(50. 0% )。总死亡率为 22. 7%。发生特发性肺炎综合征的患者较多伴发慢性移植物抗宿主病,免疫抑制剂治疗有效。结论:异基因造血干细胞移植后肺炎是移植后常见的合并症,其病因学包括感染和非感染因素,针对病因的治疗可以改善预后。
Objective: To analyze the clinical features and etiology of pneumonia after allogeneic hematopoietic stem cell transplantation. Methods: The data of 255 cases of allogeneic hematopoietic stem cell transplant recipients in Peking University Hematology Institute from 1998 to 2001 for four consecutive years were summarized. Results: Sixty-six patients with post-transplant pneumonia had cumulative incidence of 72 cases, with a total incidence of 25.9%. 50 cases of post-transplant pneumonia were cured, accounting for 75%. Etiological analysis showed that 12 cases (12.7%) of pneumonia after fine / fungal infection transplantation, 22 cases (30.6%) of cytomegalovirus pneumonia, 36 cases (50.0%) of idiopathic pneumonia syndrome %). The total mortality rate was 22.7%. Patients with idiopathic pneumonia syndrome more associated with chronic graft-versus-host disease, immunosuppressive therapy effective. CONCLUSIONS: Pneumonia after allogeneic hematopoietic stem cell transplantation is a common comorbidity after transplantation. The etiological factors include infectious and non-infectious factors. The treatment of etiology can improve the prognosis.