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目的 :探讨特比萘芬治疗真菌性角膜炎的价值。方法 :①采用琼脂稀释法 ,测定特比萘芬与二性霉素B、咪康唑、氟康唑、伊曲康唑 ,对常见的致病角膜真菌 -镰孢菌 ( 10株 )和曲霉菌 ( 10株 )的最小抑菌浓度 (MIC)。②用特比萘芬滴眼液治疗真菌性角膜炎患者 40例 ,进行临床观察 ,并与以往常用的抗真菌药物作对照研究。结果 :①特比萘芬对曲霉菌和镰孢菌均有明显的抑菌作用 ,尤其对前者的MIC均值最小 -黄曲菌 9 3 5 μg/ml,烟曲菌 16 74μg/ml。②治疗组除 1例重度患者行结膜瓣遮盖术外 ,余全部治愈 ;对照组 ,仅治愈 6例 ,经卡方检验两组的治愈率和总有效率 ,P<0 0 5 ,有统计学意义。结论 :研制特比萘芬滴眼液治疗真菌性角膜炎具有重要的临床价值。
Objective: To investigate the value of terbinafine in the treatment of fungal keratitis. Methods: (1) Determination of terbinafine, amphotericin B, miconazole, fluconazole and itraconazole by agar dilution method was carried out on common pathogenic corneal fungus-Fusarium (10 strains) Mold (10 strains) minimum inhibitory concentration (MIC). Forty patients with fungal keratitis were treated with terbinafine eye drops for clinical observation and compared with the commonly used antifungal drugs. Results: (1) Terbinafine had obvious bacteriostasis against Aspergillus and Fusarium, especially the MIC value of the former was the lowest (93.5 μg / ml) and that of Aspergillus fumigatus (16.74 μg / ml). ② In the treatment group, only 1 case of severe patients underwent conjunctival flap occlusion, all of them were cured. In the control group, only 6 cases were cured. The cure rate and total effective rate of the two groups were tested by Chi-square test (P <0.05) significance. Conclusion: The development of terbinafine eye drops for the treatment of fungal keratitis has important clinical value.