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目的探讨维持性血液透析患者血清肿瘤标志物临床检测的意义。方法选取63例行维持性血液透析治疗的终末期肾病患者,分别在透析前及达到干体重状态下测定血清CEA、CAl9-9、CA242、CAl53、CAl25、Ferritin、NSE、B-HCG、AFP、HGH、PSA和fPSA的浓度。选取63例正常健康体检者作为对照组,进行回顾性研究。结果维持性血液透析患者透析前与对照组比较,CEA、CA19-9和NSE水平差异有统计学意义(P<0.05),其他各肿瘤标志物水平差异无统计学意义(P>0.05);维持性血液透析患者透析后与对照组及透析前比较,Ferritin和CA125水平差异有统计学意义(P<0.05),透析后与透析前比较,除Ferritin和CA125之外,其他各肿瘤标志物水平差异无统计学意义(P>0.05)。结论 CEA、CAl9-9、NSE和CA125在透析治疗患者中诊断肿瘤价值同正常人相比降低。血清肿瘤标记物CA242、CAl53、B-HCG、AFP、HGH、PSA和fPSA检测诊断肿瘤价值与正常人相同。
Objective To investigate the clinical significance of serum tumor markers in maintenance hemodialysis patients. Methods Sixty-three patients with end-stage renal disease undergoing maintenance hemodialysis were enrolled in this study. Serum CEA, CAl9-9, CA242, CA153, CA125, Ferritin, NSE, B-HCG, AFP, HGH, PSA and fPSA concentrations. Sixty-three healthy volunteers were selected as the control group for retrospective study. Results The levels of CEA, CA19-9 and NSE in maintenance hemodialysis patients before dialysis were significantly different from those in control group (P <0.05). There was no significant difference in other tumor markers (P> 0.05) Compared with the control group and dialysis before dialysis, the levels of Ferritin and CA125 in hemodialysis patients were significantly different (P <0.05). After dialysis, the levels of other tumor markers except Ferritin and CA125 were significantly different No statistical significance (P> 0.05). Conclusion CEA, CAl9-9, NSE and CA125 in the dialysis patients diagnosed with tumor value decreased compared with normal. Serum tumor markers CA242, CAl53, B-HCG, AFP, HGH, PSA, and fPSA detected tumors with the same value as normal controls.