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目的 探讨脑血管意外伴抑郁症状患者应用抗抑郁药物治疗对其病程及预后的影响。方法 经CES-D筛选出伴抑郁症状的125例脑血管意外患者,随机分为两组。治疗组65名,非治疗组62名,两组在年龄,性别,神经功能缺损及CES-D评分等项目上无明显差异。治疗组予抗抑郁药物PROZAC20mgqd治疗,平均治疗时间为175±43.8天,一月及一年后再对两组进行CES-D及神经功能缺损的评定及比较。结果治疗组一月及一年后CES-D评分均有明显下降(p<0.001),神经功能恢复也明显好于非治疗组(P<0.01)。结论 脑血管意外伴抑郁症状者给予抗抑郁治疗对其病情改善和预后均有好处。
Objective To investigate the effect of antidepressant therapy on the course and prognosis of patients with cerebrovascular accident and depressive symptoms. Methods A total of 125 cases of cerebrovascular accident patients with depressive symptoms were selected by CES-D and were randomly divided into two groups. There were 65 cases in the treatment group and 62 cases in the non-treatment group. There was no significant difference between the two groups in terms of age, gender, neurological deficit and CES-D score. Treatment group with antidepressants PROZAC 20mgqd treatment, the average treatment time was 175 ± 43.8 days, January and January again after two groups of CES-D and neurological deficits were assessed and compared. Results The CES-D scores of the treatment group decreased significantly (p <0.001) after one month and one year, and the neurological function recovery was also significantly better than the non-treatment group (P <0.01). Conclusions The antidepressant therapy given to patients with cerebrovascular accident and depressive symptoms may be beneficial to their condition and prognosis.