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目的:研究多发性骨髓瘤(MM)患者中IL-6的表达水平,阐明其在MM肾损伤中的作用及临床意义。方法:采用化学发光法对80例MM肾损伤患者(32例肾功能不全不可逆者,28例肾功能不全可逆者和20例肾功能正常者)以及40例健康体检者的IL-6表达量检测并进行比较。结果:IL-6在肾功能不全不可逆者表达明显升高,与肾功能不全可逆者和MM肾功能正常者以及40例健康体检者IL-6表达比较差异有统计学意义(P<0.01);肾功能不全可逆者和MM肾功能正常者以及40例健康体检者彼此之间IL-6表达比较差异无统计学意义(P>0.05);MM患者不同分期IL-6表达差异有统计学意义(P<0.05)。结论:IL-6检测可作为MM患者肾功能不全病变程度诊断指标,为临床治疗提供帮助。
Objective: To study the expression of IL-6 in patients with multiple myeloma (MM) and to elucidate the role and clinical significance of IL-6 in MM. Methods: The chemiluminescence method was used to detect the expression of IL-6 in 80 patients with MM kidney injury (32 cases of irreversible renal insufficiency, 28 cases of renal insufficiency and 20 cases of normal renal function) and 40 healthy subjects And compare. Results: The expression of IL-6 was significantly increased in patients with irreversible renal insufficiency (P <0.01). There was significant difference in the expression of IL-6 between those with normal renal function and normal renal function, and in 40 healthy controls (P <0.01). There was no significant difference in the expression of IL-6 between the patients with normal renal insufficiency and MM with normal kidney function and 40 healthy controls (P> 0.05). The expression of IL-6 in different stages of MM patients was significantly different P <0.05). Conclusion: The detection of IL-6 can be used as a diagnostic indicator of the degree of renal insufficiency in MM patients, which can be helpful for clinical treatment.