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依替米星 10 0、2 0 0和 40 0 mg/(kg· d) ,sc给于 SD雄、雌性大鼠分别连续 9周和 2周后合笼 ,雄鼠给药至 11周 ,雌鼠给药至妊娠第 15天。实验结果表明 ,40 0 mg/(kg·d)对雄鼠、雌鼠及胎仔均有毒性 ,表现为雄鼠从给药第 4周起体重增长受到抑制 (给药 4、5、周 P<0 .0 5 ,P<0 .0 1) ,雌鼠交配前和交配后体重增长也受到抑制 (交配前给药第 11、14天 ,P<0 .0 5 ,P<0 .0 1,交配后怀孕第 7、11～ 15天 ,P<0 .0 5 ) ,且孕鼠的黄体数减少 (P<0 .0 1) ,胎仔骨骼检查见胸骨节第一中心及耻骨未骨化 ,剑突和指 ,趾骨化点减少。 2 0 mg/(kg·d)对雄、雌大鼠的体重、交配率、妊娠率 ,孕鼠的黄体数 ,着床数 ,活胎、死胎数及胎仔体重、外形、内脏组织 ,骨骼均无影响。因此依替米星是不具有一般生殖毒性的药物。
Eustomycin 10 0,2 0 0 and 40 0 mg / (kg · d), sc to SD male and female rats were caged for 9 weeks and 2 weeks after the males were administered to 11 weeks, females to Medicine until the 15th day of pregnancy. The results showed that 40 mg / (kg · d) was toxic to male, female and fetus, and the growth of male rats was inhibited from 4 weeks after administration (4,5 and 6 weeks after treatment, P < 0. 05, P <0. 01). The body weight gain of female rats before mating and after mating was also inhibited (11 and 14 days before mating, P <0.05, P <0.01, After mating pregnant 7,11 ~ 15 days, P <0. 05), and the number of pregnant rats decreased luteal (P <0. 01), fetal sternal cross section of the first center of the sternum and pubis not ossification, Xiphoid and fingers, toe reduction point. The body weight, mating rate, pregnancy rate, luteal number of pregnant rats, implants, live fetuses, stillbirths and birth weight, shape, visceral tissues and bones of 20 male and female rats at 20 mg / (kg · d) no effect. Therefore etimicin is not a general reproductive toxicity of drugs.