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目的:观察氟比洛芬酯脂微球载体注射液(商品名凯纷)治疗癌痛的疗效和副作用。方法:38例未使用阿片类药物的中重度癌性疼痛患者每天静脉注射50mg/5ml氟比洛芬酯脂微球载体注射液,分别就其疗效、生活质量改善情况以及不良反应等方面进行评价。结果:氟比洛芬酯脂微球载体注射液治疗中重度癌痛的有效率为71.05%,生活质量改善情况治疗前后有显著差异(P<0.05)。但未见一般非甾体类药物常见腹痛、消化道出血等副作用;也未见便秘、恶心、呕吐、嗜睡等阿片类药物常见不良反应。结论:氟比洛芬酯脂微球载体注射液治疗中重度癌痛疗效可靠,生活质量可得到改善,但氟比洛芬酯脂微球载体注射液不良反应发生率较低,可部分作为临床候选药品或口服吗啡替代药。
Objective: To observe the efficacy and side effects of flurbiprofen ester microspheres carrier injection (trade name Triptych) in the treatment of cancer pain. Methods: Thirty-eight patients with moderate-to-severe cancerous pain who did not use opioid were injected intravenously with 50 mg / 5 ml flurbiprofen liposome-loaded microspheres injections respectively to evaluate their curative effect, quality of life improvement and adverse reactions . Results: The effective rate of flurbiprofen ester microspheres carrier injection in the treatment of moderate to severe cancer pain was 71.05%, and the quality of life improved significantly before and after treatment (P <0.05). But no common non-steroidal drugs common abdominal pain, gastrointestinal bleeding and other side effects; nor constipation, nausea, vomiting, drowsiness and other opioid common adverse reactions. CONCLUSION: Flurbiprofen ester microspheres carrier injection is effective in treating moderate-severe cancer pain and the quality of life can be improved. However, the incidence of adverse reactions of flurbiprofen ester microspheres carrier injection is low, which may be partly used as clinical Candidate drugs or oral morphine alternative medicine.