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精子活力是衡量精液质量和男性生育能力的一个重要临床指标。精子运动所需能量来自线粒体呼吸链的氧化磷酸化,线粒体形态、数目、酶活性、DNA完整性及活性氧(ROS)产生等的改变都影响精子生理功能。线粒体自噬是一种选择性的细胞自噬途径,作为一种清除损伤的线粒体和过量产生的ROS的防御机制,确保细胞内线粒体功能稳定,促进应激环境中细胞的存活。因此,推测精子细胞可能通过线粒体自噬这一特异性的选择途径清除异常线粒体以保护精子细胞生存并维持精子活力,自噬参与了精子的发生过程。
Sperm motility is a measure of semen quality and male fertility is an important clinical indicator. Sperm motility requires energy from oxidative phosphorylation of the mitochondrial respiratory chain, changes in mitochondrial morphology, number, enzyme activity, DNA integrity, and reactive oxygen species (ROS) production that affect sperm physiological function. Mitochondrial autophagy is a selective pathway of autophagy, as a defensive mechanism of clearing damaged mitochondria and overproducing ROS, ensuring stable intracellular mitochondrial function and promoting cell survival in stressful environments. Therefore, it is speculated that spermatids may clear the abnormal mitochondria to protect spermatids and maintain sperm motility through a selective pathway of mitochondrial autophagy. Autophagy may participate in the process of spermatogenesis.