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目的探讨不同剂量垂体后叶素对量对腹腔镜子宫肌瘤剔除术中循环系统的影响。方法将100例腹腔镜子宫肌瘤剔除术患者随机分为A组和B组,A组患者给予垂体后叶素6 U在子宫肌层进行注射,B组患者给予垂体后叶素12 U在子宫肌层进行注射,观察两组患者手术情况及不同时间段心率(HR)、血压(BP)、血氧饱和度(SpO2)变化情况。结果两组患者手术时间,术中出血量、血红蛋白下降水平、术后排气时间、术后住院时间差异均无统计学意义(均P>0.05),两组患者HR和DBP在注射后3、4和5 min均有明显升高,HR在8 min和10 min明显下降,与注射后1 min水平比较,差异均有统计学意义(P<0.05),并且A组HR在5 min水平明显低于B组,差异有统计学意义(P<0.05),两组患者SBP在注射后3 min开始升高,且B组患者升高水平明显高于A组,差异有统计学意义(P<0.05)。结论腹腔镜子宫肌瘤剔除术应用小剂量垂体后叶素能有效减少术中出血量,并避免剧烈的循环波动,值得临床推广应用。
Objective To investigate the effect of different doses of vasopressin on the circulatory system in laparoscopic myomectomy. Methods 100 cases of laparoscopic myomectomy patients were randomly divided into group A and group B, group A patients given pituitary 6 U in the myometrium injection, group B patients given pituitary 12 U in the uterus The muscle layer was injected to observe the operation conditions and changes of heart rate (HR), blood pressure (BP) and oxygen saturation (SpO2) in two groups. Results There was no significant difference in the operation time, intraoperative blood loss, hemoglobin level, postoperative exhaust time and postoperative hospital stay between the two groups (all P> 0.05) 4 and 5 min respectively. The HR decreased significantly at 8 and 10 min, and the difference was statistically significant at 1 min after injection (P <0.05), and the HR of group A at 5 min was significantly lower In group B, the difference was statistically significant (P <0.05). SBP in both groups began to increase at 3 min after injection, and the level of SBP in group B was significantly higher than that in group A (P <0.05) ). Conclusion Laparoscopic myomectomy excluding small doses of pituitrin can effectively reduce the amount of intraoperative bleeding, and avoid the dramatic fluctuations in circulation, it is worthy of clinical application.