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目的探讨乌苏市维吾尔族支气管哮喘患者血小板参数的变化并分析支气管哮喘发病的危险因素,为支气管哮喘的防治提供依据。方法选取乌苏市解放军第15医院呼吸内科住院诊治的420例急性支气管哮喘患者与420例健康检查者,分别检测两组对象的血小板相关指标,并采用logistic回归模型分析支气管哮喘发生的危险因素。结果支气管哮喘组WBC、PLT计数、平均血小板体积(MPV)、血小板体积分布宽度(PDW)、中性粒细胞计数(N%)均高于健康对照组,而健康组1秒用力呼气容积占用力肺活量百分比(FEV_1/FVC%)、FEV_1%均高于支气管哮喘组,差异有统计学意义(P<0.05)。多因素logistic回归分析显示,体质指数、居住地区、家族史、吸烟史、过敏史是乌苏市维吾尔族人群患支气管哮喘的独立危险因素。结论支气管哮喘患者血小板相关指标可作为病情判断的参考指标。适当减轻体重、避免危险因素的暴露、建立良好的生活习惯可降低支气管哮喘的发生。
Objective To investigate the changes of platelet parameters in asthmatic patients with Uygur in Wusu and to analyze the risk factors for the development of bronchial asthma so as to provide evidence for the prevention and treatment of bronchial asthma. Methods Forty-two acute bronchial asthma patients and 420 healthy controls were selected from Department of Respiratory Medicine, Hospital 15th Hospital of Wusu People’s Liberation Army. The relevant indexes of platelet in two groups were detected. Logistic regression model was used to analyze the risk factors of bronchial asthma. Results WBC, PLT count, mean platelet volume (MPV), platelet volume distribution width (PDW) and neutrophil count (N%) in bronchial asthma group were higher than those in healthy control group The ratio of forced vital capacity (FEV 1 / FVC%) and FEV 1% were higher than that of bronchial asthma group, with significant difference (P <0.05). Multivariate logistic regression analysis showed that body mass index, living area, family history, smoking history and history of allergy were independent risk factors for bronchial asthma in Uighur population in Wusu City. Conclusion Platelet-related indicators of patients with bronchial asthma can be used as a reference indicator of disease. Proper weight loss, to avoid exposure of risk factors, the establishment of good habits can reduce the incidence of bronchial asthma.