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文献证实,妊娠中约有15％属ABO血型不合。用直接抗人球蛋白试验(DAT)做唯一的诊断尺度,在ABO妊娠中只找出2～10％溶血病。随着更灵敏技术的应用,其发病率可高达71％。有人指出,在ABO溶血病中,DAT假阴性可多到70％。为了评价比一般更广泛有用的筛查结果和试图查明能表示该病严重性的指标,于1977年1月至6月间将所有的新生儿的脐血进行筛查。其程序包括血型、Rh、DAT、间接Coombs(抗体筛查)和总胆红素及直接胆红素等试验
Literature confirmed that about 15% of pregnancy is an ABO blood group incompatibility. Using the direct anti-human globulin test (DAT) as the only diagnostic measure, only 2 to 10% of hemolytic disease were found in ABO pregnancies. With more sensitive techniques, the incidence can be as high as 71%. It was pointed out that in ABO hemolytic disease, DAT false negatives can be up to 70%. In order to evaluate more widely available screening results than ever before and to attempt to identify indicators that indicate the severity of the disease, all newborn umbilical cord blood was screened from January to June 1977. The procedures include blood type, Rh, DAT, indirect Coombs (antibody screening) and total bilirubin and direct bilirubin and other tests