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Matthews回顾了临床神经病学的一些发展,讨论了它们应用于临床的实际效果,及其今后发展的方向。内容如下: 对常规临床研究方法的评价鉴于中枢神经系统(CNS)的特殊构造和功能,某些可靠的研究方法在神经病学领域中难以应用。例如活体组织检查,在肌病研究中可以应用,在对于周围神经疾病则应用有些困难,而在CNS疾病时,因难在于获得正常标本作对照而极受限制。脑脊髓液检查虽属可行,但因人道考虑而难于反复进行,且其对脑疾病能提供的资料也有限。较易进行的血液化验,在CNS器质性病变时往往不能提供什么异常。脑电图描记间接而又粗糙。有实用价值的神经系统的动物模型极少。这些都是进一步研究的困难所在。
Matthews reviewed some of the advances in clinical neurology, discussed their practical clinical utility, and their future directions. The content is as follows: Evaluation of routine clinical research methods In view of the special structure and function of central nervous system (CNS), some reliable research methods are difficult to apply in the field of neurology. For example, biopsy can be applied in the study of myopathies, difficult to apply in peripheral neuropathy, and very limited in CNS diseases due to the difficulty in obtaining normal specimens for comparison. Cerebrospinal fluid tests, though feasible, are difficult to repeat because of humanitarian considerations and provide limited information on brain diseases. Easier blood tests often do not provide any abnormalities in CNS organic lesions. EEG mapping indirect and rough. There are very few animal models of neural systems of practical value. These are the difficulties of further research.