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目的探讨经皮冠脉介入治疗(PCI)对急性冠脉综合征患者C反应蛋白(CRP)水平的临床意义。方法将216例急性冠脉综合征患者分为2组,观察组136例行经皮冠状动脉成形术(PTCA)及支架植入术(STENT)。对照组80例行冠脉造影术。采用速率散射比浊法测定术前及术后血清CRP浓度。结果观察组CRP浓度术前比术后明显增高(P<0.01)。观察组术后CRP浓度与对照组比较差异有统计学意义(P<0.05),对照组CRP浓度术前术后相比差异无统计学意义(P>0.05)。结论 PCI术损伤血管内膜,可引起急性冠脉综合征患者血清CRP浓度升高,可作为PCI术后患者预后的预测指标。
Objective To investigate the clinical significance of percutaneous coronary intervention (PCI) on C-reactive protein (CRP) level in patients with acute coronary syndrome. Methods A total of 216 patients with acute coronary syndrome were divided into two groups. 136 patients in the observation group underwent percutaneous transluminal coronary angioplasty (PTCA) and stent implantation (STENT). Control group of 80 patients underwent coronary angiography. The rate of nephelometry was used to measure the serum CRP levels before and after operation. Results The CRP concentration in observation group was significantly higher than that before operation (P <0.01). The postoperative CRP concentration in the observation group was significantly different from that in the control group (P <0.05). There was no significant difference in the CRP concentration between the two groups (P> 0.05). Conclusions PCI injury of vascular intima can cause elevated serum CRP levels in patients with acute coronary syndromes and may be used as a predictor of prognosis after PCI.