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给ＳＤ雄性大鼠饮用含氟化钠、亚硒酸钠及氟化钠和亚硒酸钠的水溶液８周，观察硒对氟致睾丸脂质过氧化和微量元素铜、锌、铁、硒含量改变的影响．结果表明，氟化物可使睾丸组织中的脂质过氧化物（ＬＰＯ）含量明显增加，铜、锌、铁含量升高而硒含量降低．同时补硒对氟诱导的睾丸脂质过氧化具有明显的拮抗作用，对氟致睾丸组织中的铜升高利硒降低也有一定的拮抗作用，而对锌、铁含量升高则具有明显的协同作用。因此可以认为，氟致睾丸损害的机理与其诱发的脂质过氧化作用有关，而硒对氟致脂质过氧化则具有明显的拮抗作用．
To SD male rats drinking fluoride containing sodium, sodium selenite and sodium fluoride and sodium selenite aqueous solution for 8 weeks to observe selenium fluoride-induced testicular lipid peroxidation and trace elements copper, zinc, iron, selenium content Impact of change. The results showed that fluoride could significantly increase the content of lipid peroxides (LPO) in testis tissues, while the content of copper, zinc and iron increased while the content of selenium decreased. In the meantime, selenium supplementation has obvious antagonism on fluorine-induced testicular lipid peroxidation, antagonizes the increase of selenium in fluoride-induced testicular tissue, and has obvious synergistic effect on the increase of zinc and iron contents . Therefore, it can be considered that the mechanism of fluoride-induced testicular damage and its induced lipid peroxidation, and selenium on lipid peroxidation of fluoride has obvious antagonism.