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目的探讨奥扎格雷钠治疗急性脑梗死的临床疗效。方法将95例急性脑梗死病人随机分成治疗组(48)例和对照组(47)例。对照组给予常规治疗,治疗组在常规治疗的基础上,加用奥扎格雷钠80mg加入5%葡萄糖或生理盐水250ml中静脉滴注,每日二次。两组均治疗14d为一疗程,治疗后两组病例进行疗效比较,检查肝、肾、凝血等功能。结果两组有效率比较,有显著性差异(P<0.01)。两组病人治疗后血小板、出凝血时间、凝血酶原时间均在正常范围,未见明显不良反应。结论奥扎格雷钠治疗急性脑梗死安全有效。
Objective To investigate the clinical efficacy of ozagrel sodium in the treatment of acute cerebral infarction. Methods 95 patients with acute cerebral infarction were randomly divided into treatment group (48 cases) and control group (47 cases). The control group was given routine treatment. The treatment group was given intravenous infusion of 80 mg of ozagrel sodium, 250 mg of 5% dextrose or normal saline on the basis of routine treatment twice a day. The two groups were treated for a course of 14d, after treatment, the efficacy of two groups were compared to check the liver, kidney, blood clotting and other functions. Results There was significant difference between two groups (P <0.01). Two groups of patients after treatment of platelets, clotting time, prothrombin time in the normal range, no significant adverse reactions. Conclusion Ozagrel sodium is safe and effective in the treatment of acute cerebral infarction.