论文部分内容阅读
目的确认基于降钙素原浓度的治疗方案是否能成功地减少抗生素用量。方法将2010年9月~2013年9月满足纳入标准的患者随机分组,分为降钙素原组(n=311)和对照组(n=319);在降钙素原组中,按照预定的降钙素原浓度范围开始或者结束使用抗生素;对照组按现行标准使用抗生素。比较两组第28天和第60天的死亡率以及28 d内没有使用抗生素的天数。结果第28天及第60天,降钙素原组与对照组间死亡率没有差别。降钙素原组中的患者不使用抗生素的天数显著高于对照组。结论降钙素原指导的治疗疑似细菌感染的策略可以降低抗生素用量和选择性压力,并且没有造成明显不良医疗结果。
Objective To confirm whether a treatment regimen based on procalcitonin concentration can successfully reduce antibiotic dosage. Methods The patients who met the inclusion criteria from September 2010 to September 2013 were randomly divided into two groups: the procalcitonin group (n = 311) and the control group (n = 319). In the procalcitonin group, Of the initial concentration of procalcitonin or the end of the use of antibiotics; the control group according to the current standard antibiotics. Mortality at day 28 and day 60 and the number of days without antibiotics within 28 days were compared between the two groups. Results On day 28 and day 60, there was no difference in mortality between procalcitonin and control groups. Patients in the procalcitonin group had significantly higher days without antibiotics than the control group. CONCLUSIONS: Procalcitonin-directed strategies for the treatment of suspected bacterial infections can reduce antibiotic dosage and selective stress without causing significant adverse medical outcomes.